A protein AA-variant derived from a novel serum AA protein, SAA1 delta, in an individual from Papua New Guinea.
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Westermark P, Sletten K, Westermark GT, Raynes J, McAdam KP
A protein AA-variant derived from a novel serum AA protein, SAA1 delta, in an individual from Papua New Guinea.
Biochem Biophys Res Commun. 1996 Jun 14;223(2):320-3.
- PubMed ID
- 8670280 [ View in PubMed]
- Abstract
A major protein AA amyloid protein was purified and characterised from a Papua New Guinnean individual. This AA protein differed from all previously characterised SAA variants by the combination of Ala52, Val57, Asn60, Phe68, Phe69 and Gly72. Since the prevalence of AA-amyloidosis is unusually high in Papua New Guinea this AAdelta must originate from a novel SAAdelta which may represent a particularly amyloidogenic variant.