A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.
Article Details
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Scheidereit C, Cromlish JA, Gerster T, Kawakami K, Balmaceda CG, Currie RA, Roeder RG
A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.
Nature. 1988 Dec 8;336(6199):551-7.
- PubMed ID
- 2904654 [ View in PubMed]
- Abstract
The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.