Nucleotide sequence of a human immunoglobulin C gamma 4 gene.
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Ellison J, Buxbaum J, Hood L
Nucleotide sequence of a human immunoglobulin C gamma 4 gene.
DNA. 1981;1(1):11-8.
- PubMed ID
- 6299662 [ View in PubMed]
- Abstract
We report the nucleotide sequence of a gene encoding the constant region of a human immunoglobulin gamma 4 heavy chain (C gamma 4). These data represent the first complete sequence determination of a human CH gene. As expected from structural studies of mouse C gamma genes, the coding sequences for the CH domains and hinge segment are separated from one another by intervening DNA sequences. Comparison with genomic sequences of the mouse C gamma 1, C gamma 2a, and C gamma 2b genes shows conservation of the sequences in the constant region domains and the 3' untranslated region surrounding the presumed site of poly(A) addition.