Cycrimine on rat diaphragm.
Article Details
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Vedasiromoni JR, Ganguly DK
Cycrimine on rat diaphragm.
Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9.
- PubMed ID
- 1267542 [ View in PubMed]
- Abstract
Cycrimine hydrochloride, an anti-Parkinson drug having central cholinolytic properties, was found to cause neuromuscular blockade in the isolated rat diaphragm preparation. The neuromuscular blockade by cycrimine remained unaffected in presence of neostigmine and tetraethylammonium. Lower concentrations of cycrimine potentiated the paralytic effect of d-tubocurarine. A similar paralytic effect of cycrimine was observed in the pharmacologically denervated rat diaphragm. Responses to acetylcholine administered by retrograde i.v. injection were found to be inhibited in presence of cycrimine. These results suggest that the neuromuscular blockade by cycrimine is produced by a postsynaptic direct effect on the muscle.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cycrimine Muscarinic acetylcholine receptor M1 Protein Humans YesAntagonistDetails