Characterization of an activated human ros gene.
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Birchmeier C, Birnbaum D, Waitches G, Fasano O, Wigler M
Characterization of an activated human ros gene.
Mol Cell Biol. 1986 Sep;6(9):3109-16.
- PubMed ID
- 3785223 [ View in PubMed]
- Abstract
A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene. Both v-ros and mcf3 can encode a protein with homology to tyrosine-specific protein kinases, and both mcf3 and v-ros encode a potential transmembrane domain N terminal to the kinase domain. mcf3 probably arose during gene transfer from a normal human ros gene by the loss of a putative extracellular domain. There do not appear to be any other gross rearrangements in the structure of mcf3.