Effect of imidazoline drugs on human blood platelet aggregation.

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Petrusewicz J, Kaliszan R

Effect of imidazoline drugs on human blood platelet aggregation.

Thromb Haemost. 1985 Dec 17;54(4):784-7.

PubMed ID

2868542 [ View in PubMed

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Abstract

The effect of seven commonly used in therapy imidazoline derivatives on human blood platelet aggregation was studied. Three of the agents, i.e. clonidine, antazoline and tetryzoline were classified as partial agonists of the receptor responsible for aggregation. Two other drugs, i.e. phentolamine and tolazoline act as competitive antagonists of relatively high receptor affinity. The remaining imidazolines: xylometazoline and naphazoline effectively inhibit the platelet receptor in a non-competitive manner. The last two compounds seem to be selective alpha 2-adrenoceptor antagonists.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Xylometazoline	Alpha-2A adrenergic receptor	Protein	Humans	Yes	Agonist	Details