Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.
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Hernandez DG, Paisan-Ruiz C, McInerney-Leo A, Jain S, Meyer-Lindenberg A, Evans EW, Berman KF, Johnson J, Auburger G, Schaffer AA, Lopez GJ, Nussbaum RL, Singleton AB
Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.
Ann Neurol. 2005 Mar;57(3):453-6.
- PubMed ID
- 15732108 [ View in PubMed]
- Abstract
We have recently identified mutations in a gene leucine-rich repeat kinase-2 (LRRK2), which cause autosomal dominant Parkinson's disease. Here, we describe two families with autosomal dominant Parkinson's disease caused by a LRRK2 G2019S mutation. We present here a clinical description of patients, including 6-(18)F-fluoro-L-dopa positron emission tomography and discuss the potential implications of this mutation, which alters a conserved residue in a domain required for kinase activation.