When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor.

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Su TP, Hayashi T, Vaupel DB

When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor.

Sci Signal. 2009 Mar 10;2(61):pe12. doi: 10.1126/scisignal.261pe12.

PubMed ID
19278957 [ View in PubMed
]
Abstract

N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine-associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Dimethyltryptamine5-hydroxytryptamine receptor 2AProteinHumans
Unknown
Not AvailableDetails
DimethyltryptamineSigma non-opioid intracellular receptor 1ProteinHumans
Unknown
Not AvailableDetails