[Interaction of tolazoline and cimetidine in persistent fetal circulation of the newborn infant].

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Roll C, Hanssler L

[Interaction of tolazoline and cimetidine in persistent fetal circulation of the newborn infant].

Monatsschr Kinderheilkd. 1993 Apr;141(4):297-9.

PubMed ID

8487790 [ View in PubMed

]

Abstract

A newborn was treated with tolazoline for persistent pulmonary hypertension. Oxygenation improved during continuous infusion of the drug, but gastrointestinal bleeding occurred. Therefore, cimetidine was given. After this there was a rapid deterioration with decrease of oxygen saturation and arterial pO2 values. Tolazoline induces a dilatation of the pulmonary vascular system by stimulating H1 and H2 receptors. Blocking of H2 receptors by cimetidine abolishes the effect of tolazoline at least partially. Our case shows that the interaction between tolazoline and cimetidine is of clinical significance. The recommendation to use cimetidine as prophylaxis against gastrointestinal side-effects induced by tolazoline can no longer be maintained.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Tolazoline	Histamine H1 receptor	Protein	Humans	Unknown	Agonist	Details
Tolazoline	Histamine H2 receptor	Protein	Humans	Unknown	Agonist	Details