p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis.
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Efimova T
p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis.
Cell Cycle. 2010 Feb 1;9(3):498-05.
- PubMed ID
- 20090411 [ View in PubMed]
- Abstract
The p38delta mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38delta in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.