The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin.
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MacLeod AR, Houlker C, Reinach FC, Talbot K
The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin.
Nucleic Acids Res. 1986 Nov 11;14(21):8413-26.
- PubMed ID
- 3024106 [ View in PubMed]
- Abstract
We have determined the sequence of a 2.5 kb mRNA in human fibroblasts encoding a 248 amino acid cytoskeletal tropomyosin. The protein product of this mRNA is TM30nm, one of five tropomyosin-like proteins in human fibroblasts. The structural gene encoding this mRNA can also produce a 1.3 kb mRNA encoding a 285 amino acid skeletal muscle alpha-tropomyosin by tissue-specific alternative mRNA splicing. However, the multiple RNA-copy pseudogenes of this gene family are derived largely if not exclusively from transcripts processed according to the pattern observed in non-muscle cells.