Agonist profile of ergometrine (ergonovine) on a population of postsynaptic alpha-adrenoceptors.

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Gibson A, Carvajal A

Agonist profile of ergometrine (ergonovine) on a population of postsynaptic alpha-adrenoceptors.

J Pharm Pharmacol. 1988 Feb;40(2):137-9.

PubMed ID

2897449 [ View in PubMed

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Abstract

Ergometrine (0.02-5 microM) produced concentration-related contractions of the mouse anococcygeus muscle, which were unaffected by cocaine (2 microM) or by pretreatment of mice with 6-hydroxydopamine. Contractions were reduced by alpha-adrenoceptor antagonists; the rank order of potency was prazosin greater than phentolamine greater than yohimbine. With phenoxybenzamine as antagonist, the estimated dissociation constant (KD) for ergometrine was 0.41 microM. It is concluded that ergometrine causes direct activation of postsynaptic alpha 1-adrenoceptors, and it is suggested that it acts on the same subtype of the receptor as imidazoline agonists.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ergometrine	Alpha-1A adrenergic receptor	Protein	Humans	Yes	Agonist	Details