Antibiotics for gram-positive bacterial infections. Vancomycin, teicoplanin, quinupristin/dalfopristin, and linezolid.

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Lundstrom TS, Sobel JD

Antibiotics for gram-positive bacterial infections. Vancomycin, teicoplanin, quinupristin/dalfopristin, and linezolid.

Infect Dis Clin North Am. 2000 Jun;14(2):463-74.

PubMed ID

10829266 [ View in PubMed

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Abstract

Vancomycin is a safe, effective antibiotic for a variety of serious gram-positive infections. Because of emerging resistance in enterococci and staphylococci and the emerging threat of spread of vancomycin-resistant genes to other gram-positive organisms, judicious use of vancomycin should be promoted. Quinupristin/dalfopristin, a streptogramin antibiotic, and linezolid, an oxazolidinone, show promise against some strains of gram-positive bacteria that are resistant to vancomycin.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Teicoplanin	D-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycan	Group	Gram-positive Bacteria	Yes	Inhibitor	Details