Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K.
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Ambler RP, Scott GK
Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K.
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3732-6.
- PubMed ID
- 358199 [ View in PubMed]
- Abstract
Direct studies of the amino acid sequence of an Escherichia coli plasmid-coded penicillinase (penicillin amido-beta-lactamhydrolase, EC 3.5.2.6) are in complete agreement with results derived from the translation of the DNA sequence of a related plasmid, apart from a single amino acid substitution. This penicillinase from a Gram-negative bacterium shows 30-35% identity with functionally similar enzymes from Gram-positive bacteria. This paper should be read in conjunction with the report of the DNA sequence of the gene.