Clinical pharmacology of topiramate: a review.
Article Details
- CitationCopy to clipboard
Garnett WR
Clinical pharmacology of topiramate: a review.
Epilepsia. 2000;41 Suppl 1:S61-5.
- PubMed ID
- 10768303 [ View in PubMed]
- Abstract
Clinical success with an antiepileptic drug (AED) depends primarily on its efficacy and tolerability. Clinicians also need to have a basic understanding of an AED's pharmacokinetic characteristics, particularly those affecting the potential for drug interactions such as hepatic enzyme inhibition or induction and protein-binding displacement. Successful treatment may be complicated by pharmacokinetic characteristics such as a short half-life, nonlinear kinetics, and active metabolites. Pharmacokinetic characteristics that make a drug easy to use may affect patient adherence. In general, newer AEDs such as topiramate (TPM) are simpler to use than traditional AEDs because they have more favorable pharmacokinetic characteristics and fewer drug interactions.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Topiramate Gamma-aminobutyric acid receptor subunit alpha-1 Protein Humans YesAgonistDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Topiramate Cytochrome P450 2C19 Protein Humans UnknownInhibitorDetails