Interferon alpha receptor 2 expression by peripheral blood monocytes in patients with a high viral load of hepatitis C virus genotype 1 showing substitution of amino Acid 70 in the core region.
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Ishii K, Shinohara M, Sawa M, Kogame M, Higami K, Sano M, Morita T, Sumino Y
Interferon alpha receptor 2 expression by peripheral blood monocytes in patients with a high viral load of hepatitis C virus genotype 1 showing substitution of amino Acid 70 in the core region.
Intervirology. 2010;53(2):105-10. doi: 10.1159/000264200. Epub 2009 Dec 3.
- PubMed ID
- 19955815 [ View in PubMed]
- Abstract
BACKGROUND/AIM: When patients with chronic hepatitis C (CHC) are treated with interferon (IFN)-based therapy, achieving serum HCV-RNA negativity by week 12 (early viral response, EVR) is an important predictor of a sustained virologic response. The aim of this study was to clarify whether changes in IFN-alpha receptor 2 (IFNAR-2) expression by peripheral blood monocytes (Mo) and the EVR rate differed between patients with genotype 1b and a high viral load showing substitution of amino acid 70 in the core region of HCV (mutant, n = 20) and patients without this substitution (wild, n = 23). PATIENTS AND METHODS: Forty-three CHC patients were studied, and received pegylated IFN plus ribavirin. IFNAR-2 expression by Mo was determined using flow cytometry to measure the mean fluorescence intensity (MFI) before and up to 28 days after starting therapy. RESULTS: The EVR rate of the mutant group was significantly lower than that of the wild group (35 vs.70%). The MFI of Mo was significantly higher in the wild group than in the mutant group before and also 3, 7, and 28 days after starting therapy. CONCLUSIONS: Mutation of HCV was related to lower IFNAR-2 expression by Mo before and after starting therapy.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Interferon alfa-n1 Interferon alpha/beta receptor 1 Protein Humans YesAgonistDetails Interferon alfa-n1 Interferon alpha/beta receptor 2 Protein Humans YesAgonistDetails Interferon alfa-n3 Interferon alpha/beta receptor 1 Protein Humans YesAgonistDetails Interferon alfa-n3 Interferon alpha/beta receptor 2 Protein Humans YesAgonistDetails Peginterferon alfa-2a Interferon alpha/beta receptor 1 Protein Humans YesAgonistDetails Peginterferon alfa-2a Interferon alpha/beta receptor 2 Protein Humans YesAgonistDetails Peginterferon alfa-2b Interferon alpha/beta receptor 1 Protein Humans YesAgonistDetails Peginterferon alfa-2b Interferon alpha/beta receptor 2 Protein Humans YesAgonistDetails