Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Article Details
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Sekiguchi Y, Nakaniwa T, Kinoshita T, Nakanishi I, Kitaura K, Hirasawa A, Tsujimoto G, Tada T
Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. doi: 10.1016/j.bmcl.2009.04.076. Epub 2009 Apr 22.
- PubMed ID
- 19414254 [ View in PubMed]
- Abstract
We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ellagic acid Casein kinase II subunit alpha Protein Humans UnknownInhibitorDetails - Binding Properties
Drug Target Property Measurement pH Temperature (°C) (5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acid Casein kinase II subunit alpha IC 50 (nM) 390 N/A N/A Details Dichlororibofuranosylbenzimidazole Casein kinase II subunit alpha IC 50 (nM) 13000 N/A N/A Details Ellagic acid Casein kinase II subunit alpha IC 50 (nM) 40 N/A N/A Details Emodin Casein kinase II subunit alpha IC 50 (nM) 2000 N/A N/A Details Tetrabromo-2-Benzotriazole Casein kinase II subunit alpha IC 50 (nM) 900 N/A N/A Details