Novel roles for hERG K(+) channels in cell proliferation and apoptosis.

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Jehle J, Schweizer PA, Katus HA, Thomas D

Novel roles for hERG K(+) channels in cell proliferation and apoptosis.

Cell Death Dis. 2011 Aug 18;2:e193. doi: 10.1038/cddis.2011.77.

PubMed ID

21850047 [ View in PubMed

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Abstract

The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K(+) channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K(+) channels as future drug target in anticancer therapy is highlighted.

DrugBank Data that Cites this Article

Drugs

Doxazosin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Doxazosin	HERG human cardiac K+ channel (Protein Group)	Protein group	Humans	Unknown	Inhibitor	Details