Possible drug-drug interaction in dogs and cats resulted from alteration in drug metabolism: A mini review.

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Sasaki K, Shimoda M

Possible drug-drug interaction in dogs and cats resulted from alteration in drug metabolism: A mini review.

J Adv Res. 2015 May;6(3):383-92. doi: 10.1016/j.jare.2015.02.003. Epub 2015 Feb 24.

PubMed ID

26257936 [ View in PubMed

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Abstract

Pharmacokinetic drug-drug interactions (in particular at metabolism) may result in fatal adverse effects in some cases. This basic information, therefore, is needed for drug therapy even in veterinary medicine, as multidrug therapy is not rare in canines and felines. The aim of this review was focused on possible drug-drug interactions in dogs and cats. The interaction includes enzyme induction by phenobarbital, enzyme inhibition by ketoconazole and fluoroquinolones, and down-regulation of enzymes by dexamethasone. A final conclusion based upon the available literatures and author's experience is given at the end of the review.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Enrofloxacin	Cytochrome P450 1A2	Protein	Humans	Unknown	Inhibitor	Details