Clavulanic acid: a review.

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Saudagar PS, Survase SA, Singhal RS

Clavulanic acid: a review.

Biotechnol Adv. 2008 Jul-Aug;26(4):335-51. doi: 10.1016/j.biotechadv.2008.03.002. Epub 2008 Mar 26.

PubMed ID

18450406 [ View in PubMed

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Abstract

Natural antibiotics are almost universal secondary metabolites, not essential for the growth of the producing organisms generally produced at low growth rates or after growth has ceased. Clavulanic acid (CA), a naturally occurring powerful inhibitor of bacterial beta-lactamases is a major beta-lactam antibiotic produced by organism Streptomyces clavuligerus and is active against a wide spectrum of Gram-positive and Gram-negative bacteria. The review discusses the biosynthetic pathway, fermentative production, downstream processing and applications of CA.

DrugBank Data that Cites this Article

Drugs

Clavulanic acid

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Clavulanic acid	Bacterial beta-lactamase enzymes	Group		Yes	Inhibitor	Details