The effects of zinc deficiency on pancreatic carboxypeptidase activity and protein digestion and absorption in the rat.

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Mills CF, Quarterman J, Williams RB, Dalgarno AC

The effects of zinc deficiency on pancreatic carboxypeptidase activity and protein digestion and absorption in the rat.

Biochem J. 1967 Mar;102(3):712-8. doi: 10.1042/bj1020712.

PubMed ID

16742484 [ View in PubMed

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Abstract

1. Proteolytic enzyme activities were examined in the pancreas of zinc-deficient and control rats. 2. No change was detected in trypsin-plus-chymotrypsin activity. 3. Carboxypeptidase activity was appreciably lowered in zinc deficiency and returned rapidly to normal on zinc therapy. 4. In experiments in which U-(14)C-labelled Chlorella protein was fed no evidence was obtained which suggested that the reduction in carboxypeptidase activity had limited the rate of protein digestion or absorption. 5. The specific activity of pancreatic protein synthesized during these experiments was appreciably lower in zinc-deficient than in control rats. 6. A higher proportion of the total activity present, in each organ examined, was in the non-protein fraction in zinc-deficient rats.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Zinc acetate	Carboxypeptidase E	Protein	Humans	Unknown	Inhibitor Ligand	Details