Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative.

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Kovacs I, Maksay G, Simonyi M

Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative.

Arzneimittelforschung. 1989 Mar;39(3):295-7.

PubMed ID
2502985 [ View in PubMed
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Abstract

EGYT 3886 (dia(-)2-phenyl-2-(dimethylamino-ethoxy) - 1R - 1,7,7-trimethyl-bicyclo[2.2.1.]heptane hemifumarate) exhibiting anxiolytic and anticonvulsant properties is inactive on various binding sites of the GABAA (gamma-aminobutyric acid A) receptor/chloride ionophore complex, but is an effective inhibitor of high-affinity synaptosomal 3H-GABA uptake.

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