The role of intestinal bacteria in the transformation of sodium picosulfate.

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Kim DH, Hyun SH, Shim SB, Kobashi K

The role of intestinal bacteria in the transformation of sodium picosulfate.

Jpn J Pharmacol. 1992 May;59(1):1-5.

PubMed ID
1507649 [ View in PubMed
]
Abstract

Sodium picosulfate, a laxative, was biotransformed to 4,4'-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase). The biotransformation was activated by adding phenolic compounds such as phenol, acetaminophen and flavonoids. The enzyme activity related to this biotransformation was the highest in the contents of the caecum region of the intestine. The enzyme activity was 3.0 mumole/hr/g wet feces in humans and 0.75 in rats (pH 8.0). The optimal pH was 9.0.

DrugBank Data that Cites this Article

Drugs
Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
Picosulfuric acidArylsulfate sulfotransferaseProteinEscherichia coli O1:K1 / APEC
Unknown
Substrate
Details