Role of zinc in hemostasis: a review.

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Tubek S, Grzanka P, Tubek I

Role of zinc in hemostasis: a review.

Biol Trace Elem Res. 2008 Jan;121(1):1-8. doi: 10.1007/s12011-007-8038-y. Epub 2007 Oct 30.

PubMed ID

17968515 [ View in PubMed

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Abstract

Zinc is a multi-functional element that is found in almost 300 enzymes where it performs catalytic, co-catalytic, and/or structural functions. In 1982, Gordon et al. (Am J Clin Ntr 35:849-857, 1982) found that a low zinc diet caused poor platelet aggregation and increased bleeding tendency in adult males. This fact drew interest to the role of zinc in blood clotting. It has been shown that hyperzincemia predisposes to increased coagulability, and hypozincemia to poor platelet aggregation and increased bleeding time. The blood clotting disturbances can be regressed by appropriate zinc intake management. Considering the importance of zinc as an essential element, its participation in regulation of the equilibrium between pro- and anti-thrombotic factors originating in platelets and endothelium prompted further investigations.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Zinc chloride	Coagulation factor XI	Protein	Humans	Unknown	Activator	Details
Zinc chloride	Histidine-rich glycoprotein	Protein	Humans	Unknown	Cofactor	Details
Zinc sulfate, unspecified form	Coagulation factor XI	Protein	Humans	Unknown	Activator	Details
Zinc sulfate, unspecified form	Histidine-rich glycoprotein	Protein	Humans	Unknown	Cofactor	Details