Zinc binding to fibrinogen and fibrin.

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Marx G

Zinc binding to fibrinogen and fibrin.

Arch Biochem Biophys. 1988 Oct;266(1):285-8.

PubMed ID

3178229 [ View in PubMed

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Abstract

Zinc binding to fibrinogen and fibrin was studied by two techniques. Scatchard analysis of ultrafiltration eluates reveals that fibrinogen has multiple Zn(II)-binding sites, KD (fibrinogen) = 18 microM; n = 6. The zinc content of the "collapsed" fibrin gel supernatant was also determined by atomic absorption spectroscopy and analyzed by a Scatchard plot (KD (fibrin) = 8 microM, n = 6). In other experiments, Zn(II) did not displace 45Ca(II) from fibrin. It appears that the binding of zinc to fibrinogen or fibrin is distinct from that of calcium, and that the zinc-binding characteristics of fibrinogen and fibrin are not significantly affected by the transformation of one into the other.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Zinc	Fibrinogen alpha chain	Protein	Humans	Unknown	Not Available	Details
Zinc acetate	Fibrinogen alpha chain	Protein	Humans	Unknown	Not Available	Details
Zinc chloride	Fibrinogen alpha chain	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Fibrinogen alpha chain	Protein	Humans	Unknown	Binder	Details