Inhibition by ethambutol of mycolic acid transfer into the cell wall of Mycobacterium smegmatis.

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Takayama K, Armstrong EL, Kunugi KA, Kilburn JO

Inhibition by ethambutol of mycolic acid transfer into the cell wall of Mycobacterium smegmatis.

Antimicrob Agents Chemother. 1979 Aug;16(2):240-2. doi: 10.1128/aac.16.2.240.

PubMed ID
485133 [ View in PubMed
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Abstract

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates of Mycobacterium smegmatis. Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive inhibition was involved.

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