Human metabolism of cyproheptadine.

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Porter CC, Arison BH, Gruber VF, Titus DC, Vandenheuvel WJ

Human metabolism of cyproheptadine.

Drug Metab Dispos. 1975 May-Jun;3(3):189-97.

PubMed ID

238818 [ View in PubMed

]

Abstract

Gas-liquid chromatographic and mass, nuclear magnetic resonance, and infrared spectrometric techniques were utilized to identify some of the metabolites of cyproheptadine in the urine of human subjects who had ingested radiolabeled drug. Aromatic ring hydroxylation (followed by glucuronide conjugation), N-demethylation, and heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium, glucuronide-like conjugate of cyproheptadine. No evidence was found for metabolic changes at the tricyclic ethylene bridge in this species.

DrugBank Data that Cites this Article

Drugs

Cyproheptadine

Drug Reactions

Reaction
Cyproheptadine DB00434 UDP-glucuronosyltransferase 1-3 UDP-glucuronosyltransferase 1A4 UDP-glucuronosyltransferase 2B10 Cyproheptadine N-glucuronide DBMET03307	Details