An evidence-based review of the potential role of icatibant in the treatment of acute attacks in hereditary angioedema type I and II.

Article Details

Citation
Copy to clipboard

Floccard B, Hautin E, Bouillet L, Coppere B, Allaouchiche B

An evidence-based review of the potential role of icatibant in the treatment of acute attacks in hereditary angioedema type I and II.

Core Evid. 2012;7:105-14. doi: 10.2147/CE.S24743. Epub 2012 Sep 27.

PubMed ID
23055948 [ View in PubMed
]
Abstract

INTRODUCTION: Icatibant, a first-in-class B2 bradykinin receptor antagonist, appears to have a favorable efficacy and safety profile for the treatment of acute attacks of hereditary angioedema in adults. AIMS: To update the evidence and provide an overview of the available data on icatibant. EVIDENCE REVIEW: Peer reviewed articles published and listed in Medline Search and published updated guidelines for the treatment of acute attacks in hereditary angioedema type I and II in adults were reviewed. The validity and quality of evidence were evaluated. PLACE IN THERAPY: Clinical evidence for the treatment of acute hereditary angioedema attacks with icatibant is strong. Approximately 10% of the patients require a second dose. No serious adverse reactions have been reported. The only significant side effects consistently registered by 90% of patients are transient local pain, swelling, and erythema at the local injection site. CONCLUSION: Subcutaneously administered 30 mg icatibant has been shown to be a safe and efficacious treatment in clinical trials. It is the only specific treatment authorized for self-administration by the subcutaneous route offering increased patient independence.

DrugBank Data that Cites this Article

Drugs