Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity.

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Zhang JG, Fariss MW

Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity.

Biochem Pharmacol. 2002 Feb 15;63(4):751-4.

PubMed ID
11992644 [ View in PubMed
]
Abstract

Thenoyltrifluoroacetone (TTFA), a conventional mitochondrial complex II inhibitor, was found to inhibit purified porcine liver carboxylesterase non-competitively with a K(i) of 0.61x10(-6)M and an IC(50) of 0.54x10(-6)M. Both rat plasma and liver mitochondrial esterases were inhibited in a concentration-dependent fashion. Results indicate that TTFA is a potent inhibitor of carboxylesterase activity, in addition to its ability to inhibit mitochondrial complex II activity. Therefore, caution is warranted in using TTFA as a mitochondrial complex inhibitor in combination with esterase substrates, such as fluorescence probes or vitamin E esters.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
ThenoyltrifluoroacetoneLiver carboxylesterase 1ProteinHumans
Unknown
Not AvailableDetails