Seven-day antinociceptive effect of a sustained release vapreotide formulation.
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Betoin F, Eschalier A, Duchene-Marullaz P, Lavarenne J
Seven-day antinociceptive effect of a sustained release vapreotide formulation.
Neuroreport. 1994 Jan 31;5(5):642-4.
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- 7912964 [ View in PubMed]
- Abstract
This work studies the antinociceptive effect of a sustained (7 day) release dosage form of vapreotide, a peptidic analogue of somatostatin, in rats submitted to a nociceptive mechanical stimulus (paw pressure). One intramuscular injection (0.6 mg/animal) induced a significant antinociceptive effect for 7 complete days with a maximal increase in vocalization thresholds of 68 +/- 5% and a plateau of activity during the first 4 days. This action was totally inhibited by naloxone (1 mg kg-1, s.c.) injected 24 h or 6 days after vapreotide, suggesting an opioidergic involvement throughout the antinociceptive effect. These findings suggest potential interest in human therapy.
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