Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.

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Johnson AT, Klein ES, Gillett SJ, Wang L, Song TK, Pino ME, Chandraratna RA

Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.

J Med Chem. 1995 Nov 24;38(24):4764-7.

PubMed ID
7490725 [ View in PubMed
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Abstract

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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
TretinoinRetinoic acid receptor alphaEC 50 (nM)7N/AN/ADetails
TretinoinRetinoic acid receptor betaKd (nM)12N/AN/ADetails
TretinoinRetinoic acid receptor betaEC 50 (nM)1N/AN/ADetails
TretinoinRetinoic acid receptor gammaEC 50 (nM)0.7N/AN/ADetails
TretinoinRetinoic acid receptor gammaKd (nM)19N/AN/ADetails
TretinoinRetinoic acid receptor RXR-alphaKd (nM)9N/AN/ADetails