Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors.

Article Details

Citation

Copy to clipboard

Moriyama H, Tsukida T, Inoue Y, Kondo H, Yoshino K, Nishimura S

Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2741-4.

PubMed ID

12873505 [ View in PubMed

]

Abstract

In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Marimastat	Interstitial collagenase	Ki (nM)	1.1	N/A	N/A	Details
Marimastat	Stromelysin-1	Ki (nM)	84	N/A	N/A	Details