Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.
Article Details
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Tu N, Link JT, Sorensen BK, Emery M, Grynfarb M, Goos-Nilsson A, Nguyen B
Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.
Bioorg Med Chem Lett. 2004 Aug 16;14(16):4179-83.
- PubMed ID
- 15261266 [ View in PubMed]
- Abstract
Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Mifepristone Glucocorticoid receptor IC 50 (nM) 4.8 N/A N/A Details