Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein.
Article Details
- CitationCopy to clipboard
Deprez P, Mandine E, Gofflo D, Meunier S, Lesuisse D
Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein.
Bioorg Med Chem Lett. 2002 May 6;12(9):1295-8.
- PubMed ID
- 11965374 [ View in PubMed]
- Abstract
Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) DPI59 Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) >5000000 N/A N/A Details ISO24 Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 4400000 N/A N/A Details PAS219 Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 2300000 N/A N/A Details Phenylphosphate Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 2500000 N/A N/A Details RU78262 Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 200000 N/A N/A Details RU78300 Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 900000 N/A N/A Details