Guttiferones O and P, prenylated benzophenone MAPKAPK-2 inhibitors from Garcinia solomonensis.
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Carroll AR, Suraweera L, King G, Rali T, Quinn RJ
Guttiferones O and P, prenylated benzophenone MAPKAPK-2 inhibitors from Garcinia solomonensis.
J Nat Prod. 2009 Sep;72(9):1699-701. doi: 10.1021/np900246t.
- PubMed ID
- 19681589 [ View in PubMed]
- Abstract
Two prenylated benzophenones, guttiferones O (1) and P (2), were isolated from the stem bark of the Papua New Guinean plant Garcina solomonensis. The structures of these compounds and their relative configurations were determined by spectroscopic methods. Both compounds inhibited the phosphorylation of the synthetic biotinylated peptide substrate KKLNRTLSVA by the serine/threonine protein kinase MAPKAPK-2 with IC(50) values of 22.0 microM.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Staurosporine MAP kinase-activated protein kinase 2 IC 50 (nM) 150 N/A N/A Details