Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase.
Article Details
- CitationCopy to clipboard
Maccallini C, Patruno A, Besker N, Ali JI, Ammazzalorso A, De Filippis B, Franceschelli S, Giampietro L, Pesce M, Reale M, Tricca ML, Re N, Felaco M, Amoroso R
Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase.
J Med Chem. 2009 Mar 12;52(5):1481-5. doi: 10.1021/jm800846u.
- PubMed ID
- 19203270 [ View in PubMed]
- Abstract
New acetamidines structurally related to N-(3-(aminomethyl)benzyl)acetamidine (1, W1400) were designed as inhibitors of inducible nitric oxide synthase (iNOS). Six compounds were found to be selective for iNOS over endothelial nitric oxide synthase (eNOS), and among them, the most active and selective compound was the N-benzylacetamidine 2. A docking study was also performed to shed light on the effects of the structural modifications on the interaction of the designed inhibitors with the NOS.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) N-[3-(aminomethyl)benzyl]acetamidine Nitric oxide synthase, endothelial IC 50 (nM) 1100000 N/A N/A Details N-[3-(aminomethyl)benzyl]acetamidine Nitric oxide synthase, inducible IC 50 (nM) 330 N/A N/A Details