Diversity-oriented synthesis: exploring the intersections between chemistry and biology.

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Tan DS

Diversity-oriented synthesis: exploring the intersections between chemistry and biology.

Nat Chem Biol. 2005 Jul;1(2):74-84.

PubMed ID

16408003 [ View in PubMed

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Abstract

Diversity-oriented synthesis (DOS) is an emerging field involving the synthesis of combinatorial libraries of diverse small molecules for biological screening. Rather than being directed toward a single biological target, DOS libraries can be used to identify new ligands for a variety of targets. Several different strategies for library design have been developed to target the biologically relevant regions of chemical structure space. DOS has provided powerful probes to investigate biological mechanisms and also served as a new driving force for advancing synthetic organic chemistry.

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Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Fexaramine	Bile acid receptor	EC 50 (nM)	25	N/A	N/A	Details