Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors.
Article Details
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Foley LH, Palermo R, Dunten P, Wang P
Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors.
Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72.
- PubMed ID
- 11327602 [ View in PubMed]
- Abstract
The 5,5-disubstitutedpyrimidine-2,4,6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione Stromelysin-1 IC 50 (nM) 2000 N/A N/A Details