N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity.

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Gaster LM, Joiner GF, King FD, Wyman PA, Sutton JM, Bingham S, Ellis ES, Sanger GJ, Wardle KA

N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity.

J Med Chem. 1995 Nov 24;38(24):4760-3.

PubMed ID

7490724 [ View in PubMed

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Abstract

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Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Piboserod	5-hydroxytryptamine receptor 4	IC 50 (nM)	0.63	N/A	N/A	Details