Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.
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Fujieda H, Usui S, Suzuki T, Nakagawa H, Ogura M, Makishima M, Miyata N
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.
Bioorg Med Chem Lett. 2007 Aug 1;17(15):4351-7. Epub 2007 May 13.
- PubMed ID
- 17524643 [ View in PubMed]
- Abstract
To find novel PPARdelta-selective agonists, we designed and synthesized phenylpropanoic acid derivatives bearing 6-substituted benzothiazoles. Optimization of this series led to the identification of a potent and selective PPARdelta agonist 17. Molecular modeling suggested that compound 17 occupies the Y-shaped pocket of PPARdelta appropriately.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Cardarine Peroxisome proliferator-activated receptor delta EC 50 (nM) 85 N/A N/A Details