Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.
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Faucher N, Martres P, Laroze A, Pineau O, Potvain F, Grillot D
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.
Bioorg Med Chem Lett. 2008 Jan 15;18(2):710-5. Epub 2007 Nov 21.
- PubMed ID
- 18060776 [ View in PubMed]
- Abstract
Starting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARalpha agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound are reported.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) GW-590735 Peroxisome proliferator-activated receptor alpha EC 50 (nM) 4 N/A N/A Details