The discovery of equipotent PPARalpha/gamma dual activators.
Article Details
- CitationCopy to clipboard
Martres P, Faucher N, Laroze A, Pineau O, Fouchet MH, Potvain F, Grillot D, Beneton V
The discovery of equipotent PPARalpha/gamma dual activators.
Bioorg Med Chem Lett. 2008 Dec 1;18(23):6251-4. doi: 10.1016/j.bmcl.2008.09.094. Epub 2008 Oct 1.
- PubMed ID
- 18947994 [ View in PubMed]
- Abstract
We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) GW-590735 Peroxisome proliferator-activated receptor alpha EC 50 (nM) 4 N/A N/A Details