Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.
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Martinez A, Gil C, Perez DI
Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.
Int J Alzheimers Dis. 2011;2011:280502. doi: 10.4061/2011/280502. Epub 2011 Jun 30.
- PubMed ID
- 21760986 [ View in PubMed]
- Abstract
Glycogen synthase kinase 3 (GSK-3), a proline/serine protein kinase ubiquitously expressed and involved in many cellular signaling pathways, plays a key role in the pathogenesis of Alzheimer's disease (AD) being probably the link between beta-amyloid and tau pathology. A great effort has recently been done in the discovery and development of different new molecules, of synthetic and natural origin, able to inhibit this enzyme, and several kinetics mechanisms of binding have been described. The small molecule called tideglusib belonging to the thiadiazolidindione family is currently on phase IIb clinical trials for AD. The potential risks and benefits of this new kind of disease modifying drugs for the future therapy of AD are discussed in this paper.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tideglusib Glycogen synthase kinase-3 beta Protein Humans YesAntagonistDetails