Multiple-dose pharmacokinetics of moxisylyte after oral administration to healthy volunteers.

Article Details

Citation
Copy to clipboard

Costa P, Bressolle F, Jarroux E, Sarrazin B, Mosser J, Navratil H, Galtier M

Multiple-dose pharmacokinetics of moxisylyte after oral administration to healthy volunteers.

J Pharm Sci. 1993 Sep;82(9):968-71.

PubMed ID
8229699 [ View in PubMed
]
Abstract

The pharmacokinetics of moxisylyte in plasma and urine was investigated after oral administration. Twelve subjects were treated orally, twice daily with 240 mg of the drug for 6 days; on day 7, the subjects received a last dose of 240 mg of moxisylyte. Moxisylyte was assayed in plasma and urine by a specific HPLC method with fluorimetric detection. Moxisylyte was absorbed rapidly and changed to its metabolites immediately after drug administration; unchanged moxisylyte was not found in plasma. Two metabolites were found in plasma and urine: conjugated desacetylmoxisylyte (DAM) and the conjugate of desmethylated DAM (MDAM). The pharmacokinetic parameters determined after the first oral administration were not modified on multiple dosing. The apparent elimination half-lives of conjugated DAM and MDAM were 2.3 and 3.5 h, respectively. Elimination of these two metabolites in urine averaged 50 and 10%, respectively.

DrugBank Data that Cites this Article

Drugs