Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain.

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Narita N, Hashimoto K, Tomitaka S, Minabe Y

Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain.

Eur J Pharmacol. 1996 Jun 20;307(1):117-9.

PubMed ID

8831113 [ View in PubMed

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Abstract

The interactions of selective serotonin reuptake inhibitors and tricyclic antidepressants with subtypes of sigma receptors were investigated. The rank order of affinity (Ki values) from competition experiments of [3H](+)-pentazocine binding to sigma 1 sites was: fluvoxamine > sertraline > S(+)-fluoxetine > (+/-)-fluoxetine > citalopram > imipramine > paroxetine > desipramine > R(-)-fluoxetine > (+/-)-norfluoxetine. The Ki values of all drugs for sigma 2 sites were more than 1000 nM. Furthermore, all drugs were more potent at sigma 1 sites than at sigma 2 sites. These findings suggest that sigma receptors (sigma 1 site) may play, in some way, a role in the actions of selective serotonin reuptake inhibitors.

DrugBank Data that Cites this Article

Drugs

Sertraline

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Sertraline	Sigma receptor (Protein Group)	Protein group	Humans	Unknown	Inhibitor Binder	Details