Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922).
Article Details
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Mulamba GB, Hu A, Azad RF, Anderson KP, Coen DM
Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922).
Antimicrob Agents Chemother. 1998 Apr;42(4):971-3.
- PubMed ID
- 9559825 [ View in PubMed]
- Abstract
A human cytomegalovirus mutant that was isolated for resistance (10-fold) to the antisense oligonucleotide fomivirsen (ISIS 2922) exhibited cross-resistance to a modified derivative of fomivirsen with an identical base sequence but little or no resistance to an oligonucleotide with an unrelated sequence. No changes in the mutant's DNA corresponding to the fomivirsen target sequence were found.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Fomivirsen 30 kDa immediate-early protein 2 Protein Human cytomegalovirus (strain Towne) YesAntisense oligonucleotideDetails Fomivirsen 45 kDa immediate-early protein 2 Protein Human cytomegalovirus (strain Towne) YesAntisense oligonucleotideDetails