Effects of cyproheptadine and pizotifen on central muscarinic receptors.
Article Details
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Richards MH
Effects of cyproheptadine and pizotifen on central muscarinic receptors.
Eur J Pharmacol. 1991 Apr 3;195(3):403-5.
- PubMed ID
- 1868883 [ View in PubMed]
- Abstract
The affinities of cyproheptadine, pizotifen and (+/-)-quinuclidinyl xanthane-9-carboxylate hemioxylate (QNX) were determined at muscarinic autoreceptors and postsynaptic (IP1 formation) receptors in rat hippocampal slices. The affinity values for QNX were 8.2 and 8.5 respectively. Cyproheptadine and pizotifen were less potent than QNX. Pizotifen was slightly (2-fold) less active at antagonizing IP1 formation than blocking the autoreceptors whereas cyproheptadine was equally active at antagonizing the two hippocampal muscarinic receptors.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Pizotifen Muscarinic acetylcholine receptor M2 Protein Humans UnknownAntagonistDetails