[Effect of three herbal extracts on cytochrome P450 and possibility of interaction with drugs].

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Yokotani K, Chiba T, Sato Y, Nakanishi T, Murata M, Umegaki K

[Effect of three herbal extracts on cytochrome P450 and possibility of interaction with drugs].

Shokuhin Eiseigaku Zasshi. 2013;54(1):56-64.

PubMed ID

23470874 [ View in PubMed

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Abstract

Herb-drug interactions are mainly mediated by hepatic cytochrome P450 (CYP) enzymes. Here, we examined the effect of three herbs (valerian, salacia and black cohosh) on CYP activity in vivo in mice and in liver microsomes in vitro. Extracts which showed activity in the preliminary tests were then fed to mice at various doses (0, 0.5, 1.5 and 4.5%). Valerian did not show any effect on hepatic CYPs. Black cohosh increased the liver weight, total CYP content and CYP activities (2B and 3A) in a dose-dependent manner (up to 4.5%). Salacia inhibited CYP1A2 activity in liver microsomes in vitro. Also, salacia at the dietary dose of 4.5% suppressed body weight gain, decreased hepatic total CYP content and increased CYP activities (1A1, 2B and 2C). These findings suggest that black cohosh and salacia at high dose affect the activity of hepatic CYPs, and therefore may interact with drugs that are metabolized by CYP.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Black cohosh	Cytochrome P450 1A2	Protein	Humans	No	Inhibitor	Details