The biotransformation and disposition of bronopol following topical and intravenous administration to rats.

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Buttar HS, Downie RH

The biotransformation and disposition of bronopol following topical and intravenous administration to rats.

Toxicol Lett. 1980 Jul;6(2):101-7.

PubMed ID
7414618 [ View in PubMed
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Abstract

Approx. 40% of the topically applied dose of antibacterial agent [14C] bronopol([14C]BP) was absorbed through the rat skin within 24 h. Of the applied radioactivity, about 19% was excreted in the urine, feces and expired air. The 24 h recoveries of 14C in the urine and expired air were 15 and 2%, respectively, of the dose applied to the skin, and 74 and 9%, respectively, of the dose given intravenously. The TLC of the urines showed three metabolites, but no unchanged [14C]BP in both groups. The results suggest that rat skin is quite permeable to bronopol.

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