Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response.

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Visioli F, Giordano E, Nicod NM, Davalos A

Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response.

Front Physiol. 2012 Feb 29;3:42. doi: 10.3389/fphys.2012.00042. eCollection 2012.

PubMed ID

22393325 [ View in PubMed

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Abstract

Essential fatty acids cannot be synthesized de novo by mammals and need to be ingested either with the diet or through the use of supplements/functional foods to ameliorate cardiovascular prognosis. This review focus on the molecular targets of omega 3 fatty acids and conjugated linoleic acid, as paradigmatic molecules that can be exploited both as nutrients and as pharmacological agents, especially as related to cardioprotection. In addition, we indicate novel molecular targets, namely microRNAs that might contribute to the observed biological activities of such essential fatty acids.

DrugBank Data that Cites this Article

Drugs

Fish oil

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fish oil	Free fatty acid receptor 4	Protein	Humans	Yes	Agonist Inhibits downstream inflammation cascades	Details
Fish oil	Free radicals	Group	Humans	Unknown	Not Available	Details
Fish oil	Prostaglandin G/H synthase 2	Protein	Humans	Yes	Inhibitor	Details
Fish oil	Sodium channel protein (Protein Group)	Protein group	Humans	Unknown	Inhibitor	Details
Fish oil	Voltage gated L-type calcium channel (Protein Group)	Protein group	Humans	Unknown	Inhibitor	Details